Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC055
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-09-19 09:19
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment old patient tblCarboma 100mg 3x1,caps Madopar HBS 125mg2x1

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 36 individuals with a value less than 0.69 were subsequently diagnosed with PD. That is, 85.71% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.69 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 33, 'TN': 25, 'TP': 9, 'FP': 5}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 26, 'TN': 21, 'TP': 16, 'FP': 9}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 31, 'TN': 28, 'TP': 11, 'FP': 2}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 2, 'TN': 2, 'TP': 40, 'FP': 28}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 12.864
timePerCircleCoV 0.268728
timePerCircleSlope -0.0814488
meanError 2.21104
tremorFreq 6.64062
tremorRelPower 24.574
tremorGyroAmpMean 0.0178447
tremorGyroAmpSlope 0.00102518
tremorGyroAmpCoV 0.317298
tremorCoordAmpMean 0.131863
tremorCoordAmpSlope 0.0194862
tremorCoordAmpCoV 2.03273
tremorAccAmpMean 0.0343658
tremorAccAmpSlope 0.00272485
tremorAccAmpCoV 0.344083
tremorPcRelVar 0.616
tremorPcX 0.330162
tremorPcY -0.943924

Circle Segment 1

Duration 19.84 s, Accuracy Estimate 1.009 (lower is better)

Circle Segment 2

Duration 16.24 s, Accuracy Estimate 1.764 (lower is better)

Circle Segment 3

Duration 13.52 s, Accuracy Estimate 1.483 (lower is better)

Circle Segment 4

Duration 15.24 s, Accuracy Estimate 1.491 (lower is better)

Circle Segment 5

Duration 12.08 s, Accuracy Estimate 1.43 (lower is better)

Circle Segment 6

Duration 12.8 s, Accuracy Estimate 2.022 (lower is better)

Circle Segment 7

Duration 10.6 s, Accuracy Estimate 3.642 (lower is better)

Circle Segment 8

Duration 9.04 s, Accuracy Estimate 4.464 (lower is better)

Circle Segment 9

Duration 9.28 s, Accuracy Estimate 2.204 (lower is better)

Circle Segment 10

Duration 10.0 s, Accuracy Estimate 2.601 (lower is better)

Spiral

numSpirals 5
timePerSpiralMean 44.536
timePerSpiralCoV 0.134861
timePerSpiralSlope -0.0403269
meanError 2.6586
tremorFreq 6.25
tremorRelPower 23.1403
tremorGyroAmpMean 0.0229533
tremorGyroAmpSlope 0.00173749
tremorGyroAmpCoV 0.408433
tremorCoordAmpMean 0.0434536
tremorCoordAmpSlope 0.000553745
tremorCoordAmpCoV 0.443529
tremorAccAmpMean 0.0796551
tremorAccAmpSlope 0.000196799
tremorAccAmpCoV 0.126484
tremorPcRelVar 0.811574
tremorPcX -0.59256
tremorPcY 0.805527

Spiral Segment 1

Duration 51.96 s, Accuracy Estimate 1.892 (lower is better)

Spiral Segment 2

Duration 39.28 s, Accuracy Estimate 1.912 (lower is better)

Spiral Segment 3

Duration 49.52 s, Accuracy Estimate 5.616 (lower is better)

Spiral Segment 4

Duration 38.6 s, Accuracy Estimate 1.765 (lower is better)

Spiral Segment 5

Duration 43.32 s, Accuracy Estimate 2.108 (lower is better)

Elel

eDurationMean 0.541094
eDurationStd 0.141089
eDurationStdnorm 0.260747
eDurationMedian 0.535
eDurationQuartdelta 0.1725
eDurationQuartdeltanorm 0.32243
eDurationKurt 3.95368
eDurationTrenddiff -0.155
eDurationTrendratio 0.744856
eWidthMean 2.79338
eWidthStd 1.52194
eWidthStdnorm 0.54484
eWidthMedian 2.5155
eWidthQuartdelta 1.5795
eWidthQuartdeltanorm 0.627907
eWidthKurt 9.79408
eWidthTrenddiff -0.5265
eWidthTrendratio 0.82
eHeightMean 8.36916
eHeightStd 3.66087
eHeightStdnorm 0.437424
eHeightMedian 7.839
eHeightQuartdelta 3.042
eHeightQuartdeltanorm 0.38806
eHeightKurt 6.81298
eHeightTrenddiff -2.5155
eHeightTrendratio 0.724359
eAspectMean 0.338186
eAspectStd 0.108152
eAspectStdnorm 0.319801
eAspectMedian 0.316625
eAspectQuartdelta 0.163226
eAspectQuartdeltanorm 0.515517
eAspectKurt 2.3722
eAspectTrenddiff 0.0266354
eAspectTrendratio 1.08851
eSlantMean -0.027396
eSlantStd 0.13046
eSlantStdnorm -4.76203
eSlantMedian -0.0197712
eSlantQuartdelta 0.149901
eSlantQuartdeltanorm -7.58179
eSlantKurt 5.13246
eSlantTrenddiff 0.0228315
eRtopMean 0.72948
eRtopStd 0.142892
eRtopStdnorm 0.195882
eRtopMedian 0.737634
eRtopQuartdelta 0.135568
eRtopQuartdeltanorm 0.183788
eRtopKurt 4.64098
eRtopTrenddiff -0.0668949
eRbotMean 0.837015
eRbotStd 0.346389
eRbotStdnorm 0.413838
eRbotMedian 0.732143
eRbotQuartdelta 0.378579
eRbotQuartdeltanorm 0.517084
eRbotKurt 3.29824
eRbotTrenddiff 0.078869
eRrightMean 0.862743
eRrightStd 0.0958671
eRrightStdnorm 0.111119
eRrightMedian 0.875216
eRrightQuartdelta 0.14672
eRrightQuartdeltanorm 0.167639
eRrightKurt 2.58077
eRrightTrenddiff 0.00915381
eRleftMean 0.413764
eRleftStd 0.1491
eRleftStdnorm 0.360351
eRleftMedian 0.407051
eRleftQuartdelta 0.162375
eRleftQuartdeltanorm 0.398905
eRleftKurt 3.4365
eRleftTrenddiff -0.0430068
lDurationMean 0.930714
lDurationStd 0.237549
lDurationStdnorm 0.255233
lDurationMedian 0.915
lDurationQuartdelta 0.315
lDurationQuartdeltanorm 0.344262
lDurationKurt 3.6987
lDurationTrenddiff -0.265
lDurationTrendratio 0.742718
lWidthMean 4.30894
lWidthStd 2.15279
lWidthStdnorm 0.499611
lWidthMedian 3.51
lWidthQuartdelta 2.77875
lWidthQuartdeltanorm 0.791667
lWidthKurt 3.64036
lWidthTrenddiff -2.223
lWidthTrendratio 0.55814
lHeightMean 19.6861
lHeightStd 4.68648
lHeightStdnorm 0.23806
lHeightMedian 18.954
lHeightQuartdelta 5.499
lHeightQuartdeltanorm 0.290123
lHeightKurt 3.59232
lHeightTrenddiff -4.914
lHeightTrendratio 0.770492
lAspectMean 0.213565
lAspectStd 0.0755174
lAspectStdnorm 0.353604
lAspectMedian 0.202703
lAspectQuartdelta 0.115218
lAspectQuartdeltanorm 0.56841
lAspectKurt 2.64576
lAspectTrenddiff -0.028219
lAspectTrendratio 0.86153
lSlantMean 0.0849206
lSlantStd 0.101711
lSlantStdnorm 1.19772
lSlantMedian 0.0838323
lSlantQuartdelta 0.130914
lSlantQuartdeltanorm 1.56162
lSlantKurt 3.33074
lSlantTrenddiff -0.00736175
lRtopMean 0.854694
lRtopStd 0.128671
lRtopStdnorm 0.150546
lRtopMedian 0.875
lRtopQuartdelta 0.153874
lRtopQuartdeltanorm 0.175856
lRtopKurt 2.9283
lRtopTrenddiff 0.099839
lRbotMean 0.554785
lRbotStd 0.434779
lRbotStdnorm 0.783689
lRbotMedian 0.466667
lRbotQuartdelta 0.4232
lRbotQuartdeltanorm 0.906858
lRbotKurt 10.2715
lRbotTrenddiff 0.0348837
lRrightMean 0.925699
lRrightStd 0.0727825
lRrightStdnorm 0.0786243
lRrightMedian 0.951872
lRrightQuartdelta 0.0877506
lRrightQuartdeltanorm 0.0921874
lRrightKurt 3.33852
lRrightTrenddiff 0.0319369
lRleftMean 0.287048
lRleftStd 0.184298
lRleftStdnorm 0.642045
lRleftMedian 0.212766
lRleftQuartdelta 0.258971
lRleftQuartdeltanorm 1.21717
lRleftKurt 2.56406
lRleftTrenddiff -0.00581328

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

Elel Segment 13

FITTS Short Modified

meanTouchScore 0.926162
sumTouchScores 14.8186
meanMovementTime 1.10733
numTouches 16
undershootPercentage 0
overshootPercentage 12.5

FITTS Long Modified

meanTouchScore 0.85963
sumTouchScores 10.3156
meanMovementTime 1.59636
numTouches 12
undershootPercentage 8.33333
overshootPercentage 16.6667

ZigZag

numZigzags 4
timePerZigzagMean 49.12
timePerZigzagCoV 0.0910038
timePerZigzagSlope 0.0693811
meanError 2.71272
tremorFreq 7.22656
tremorRelPower 21.5806
tremorGyroAmpMean 0.0464018
tremorGyroAmpSlope -0.000908073
tremorGyroAmpCoV 0.426876
tremorCoordAmpMean 0.093745
tremorCoordAmpSlope -0.000678377
tremorCoordAmpCoV 0.483768
tremorAccAmpMean 0.0677277
tremorAccAmpSlope -0.000488724
tremorAccAmpCoV 0.425423
tremorPcRelVar 0.713475
tremorPcX -0.569796
tremorPcY 0.821786

ZigZag Segment 1

Duration 43.28 s, Accuracy Estimate 2.335 (lower is better)

ZigZag Segment 2

Duration 48.52 s, Accuracy Estimate 2.364 (lower is better)

ZigZag Segment 3

Duration 50.8 s, Accuracy Estimate 2.768 (lower is better)

ZigZag Segment 4

Duration 53.88 s, Accuracy Estimate 3.383 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 21.528
timePerZigzagCoV 0.235024
timePerZigzagSlope -0.0362319
zigzagHeightMean 71.8755
zigzagHeightCoV 0.091288
zigzagHeightSlope 0.0191144
meanError 0.0701801
tremorFreq 6.93359
tremorRelPower 26.016
tremorGyroAmpMean 0.0395703
tremorGyroAmpSlope -0.00206865
tremorGyroAmpCoV 0.39637
tremorCoordAmpMean 0.105678
tremorCoordAmpSlope 0.000349112
tremorCoordAmpCoV 0.662406
tremorAccAmpMean 0.0616614
tremorAccAmpSlope -0.000725345
tremorAccAmpCoV 0.368736
tremorPcRelVar 0.728512
tremorPcX -0.0200811
tremorPcY -0.999798

ZigZag Offset Segment 1

Duration 20.84 s, Accuracy Estimate 0.106 (lower is better)

ZigZag Offset Segment 2

Duration 23.56 s, Accuracy Estimate 0.075 (lower is better)

ZigZag Offset Segment 3

Duration 20.32 s, Accuracy Estimate 0.033 (lower is better)

ZigZag Offset Segment 4

Duration 28.4 s, Accuracy Estimate 0.084 (lower is better)

ZigZag Offset Segment 5

Duration 14.52 s, Accuracy Estimate 0.052 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.76}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.69}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.8416245561611373}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9061098070648417}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.7978055543766501}